The Zonal Project Directorate (erstwhile Zonal Coordinating Unit), Zone-II began its journey from the office premises located within the Directorate of Extension Education Complex of B.C.K.V., Mohanpur, Nadia, West Bengal with the specific objective to monitor and evaluate the Lab to Land Programme (LLP), country wide launched in the year 1979 in celebration of the ICAR Golden Jubilee Year and drawing fund support from the Cess Fund of ICAR.

Alongside, it was entrusted with the responsibility to monitor and guide the activities of KVKs which were gradually coming up that time with great future promise as District Level First Line Agricultural Institutions. The initial operational jurisdiction of the Unit was spread over West Bengal, Orissa and A&N Islands. However, due to demanding administrative reasons, the state of Bihar was subsequently brought under the fold of Zone-II in the year 1991 in lieu of Orissa, which was then shifted under Zone VII. The jurisdiction of ZPD was further extended to include the newly created state of Jharkhand in the year 2000. After ten years of its operation from B.C.K.V., the office of the then ZPD-II was shifted to Veterinary College Campus, Belgachia, Kolkata for required infrastructural facilities. However, conversion of Veterinary College in to West Bengal University of Animal and Fishery Sciences again necessitated the Unit to shift its office to NBSS&LUP Campus, Salt Lake, Kolkata in the year 1996.